A brief chronological history of CINDEFI 


On October 5th (day of the launch of Sputnik) is born the speciality of Industrial Microbiology (or industrial fermentations) at the faculty. Ertola begins working only in lactic acid in a laboratory of the Pharmaceutical Industries subject. Balatti is incorporated in a few months.


Industrial fermentations section is created in the Department of Technology. The first shaker and fermenter is built. This year, the first volume of Biotechnology & Bioengineering is published. It is also published the first book of Biochemical Engineering of Steel.


Mazza and several research grantees are incorporated. The Nobel Prize in medicine, Chain, visits the Institute (62). It begins the teaching of Biochemical Engineering for Engineering with the first programme of classes that the country has, and there are also teachings of fermentation processes for Chemicals. Cuevas and Daguerre, both chemicals, incorporates into the sector. With the support of CONICET and Ronco (while Frondizi is President) many equipment is acquired.


Ertola goes for a stay at the University College of London with a scholarship of CONICET. He attends the II International Congress of Fermentation in London. Contacts with Pirt, Tempest, Humphrey, Gaden, Herbert and others. Segovia joins the Sector of Fermentations.


Balatti remains in the Health Institute of Rome, where Chain had designed and built many equipment and instrumentation. At there, the first electrode of dissolved O2 is built.  There are many publications: the first work of Biotechnology & Bioengineering Research and one of the first work in the world about an air-lift reactor, and other about the transfer of oxygen in agitated erlenmeyer, in Industry and Chemistry.


It is taught the first course of Fermentation Processes for graduates, which is suspended a day by the overthrow of Illia (June 28).


Ertola, attends the III International Congress of fermentation in New Brunswick (USA), (68) as chairman of a section. He is assigned as a member of the sector of fermentation of the IUPAC. It is published the first work on Rhizobium in Soil Science.


It is published a new work on bacterial amylases in Applied Microb. (70). Cuevas makes a stay at MIT (USA),(70-71) with a scholarship from CONICET to work with an air-lift reactor and Segovia (71-72) stays at Braunschweig with a German grant to study about the use of the nylon waste by microbial way. Ertola is designed as a member of the Editorial Board of the J. Chem. Tech. and Biotech (72).


The Center, sponsored by CONICET, CIC and UNLP, is created in February. Ertola is the internal director for a few months. Balatti assumes the charge. Cuevas goes to Salta and Daguerre leaves the specialty.


Yantorno joins as research grantee and Venturini and Gallego as support staff (75). Segovia moves to San Luis. Mignone (78) and Voget (79) are admitted as research grantees and Figari (78) as technical support staff. Yantorno joins as assistant researcher (79). Boiardi (80), Arcas (80) and Hours (81) are incorporated as research grantees and Castro as support staff (81). The first National Meeting of Biological Nitrogen Fixation takes place (81) . It is given a course of Fermentation Technology applied to Rhizobium, sponsored by UNESCO. Balatti renounces the direction (82). Massaldi assumes the charge.


Ertola is assigned as Director and also assumes the position of Executive Secretary of the GNP of SECYT (83). Lopez and Galar they join as support staff. Participation in the VII International Biotechnology Congress, N. Delhi, India, (Ertola, 84).  In this congress, the name of Biotechnology is adopted for the first time in replacement of Fermentation, as it was called in all the previous ones. Yantorno is assigned as associate researcher.


Participation in the VII Global Impacts of Applied Microbiology, Finland, and in the 32th General Assembly, IUPAC, Lyon (Ertola, 84). It isdictated the Latin-American course of fermentation processes in biotechnology granted by UNESCO. J.S. Pirt participates as a teacher, among others. Boiardi and Mignone join the career as assistant investigators. Yantorno goes for a stay as a research grantee of CONICET in the Pasteur Institute in Paris. Ertola contacts with Neijssel from the Department of Microbiology of the University of Amsterdam. Production of inoculant technology is transferred to Chemical Synthesis.
Ertola participates in the OEA Meeting of biotechnology in Washington and in the Latin American Congress of chemistry at Bogotá (86). Voget joins as assistant researcher (86). Ertola assumes as Director of the CABBIO and attends the IV European Biotechnology Congress in Amsterdam (87). Brelles Mariño is incorporated as a research grantee and Dorta is admitted as a research grantee of the University of Venezuela (87). Boiardi attends at the Dept. of Microbiology of the University of Amsterdam with a grant of the EEC (88).
Yantorno, Boiardi and Ertola attend the VIII International Biotechnology Congress, Paris (88). It is dictated the course of processes in biotechnology in Brazil (88). Mignone was assigned as research associate (88). Hozbor (88), Avignone Rossa and Inchaurrondo (89) are admitted as research grantees. Ertola renounces the Direction. Yantorno is elected as Director (89). Rodriguez joins as research grantee (89), Hours and Arcas are designated as research assistants (89). A. Rossa performed a one month course in Braunschweig. An agreement with Biagro for transfer of technology on lactase is signed in 1990. Yantorno attends the Pasteur Institute and a joint project takes form. Ertola and Yantorno participate in the V European Biotechnology Congress, Denmark. The collaboration agreement between the Department of Microbiology of the University of Amsterdam (O. Neijssel) and the CINDEFI (Boiardi), is signed with support of the EEC. Flores joins as a thesis developer. Mignone publishes as only author his original model on KLa in Chem. Eng. Science. Boiardi was assigned as a research associate.
Tangorra and De Vargas (91), Bernava, Diaz and Bernier (92) assume as support staff. Flores does an international course in Guatemala (91). Hours attends a course of 5 months (JICA, 91) and later goes to Osaka, Japan, for a stay of a year with Prof. Sakai (93). An agreement of CABBIO project on pertussis vaccine is signed between the CINDEFI (Yantorno), IDEHU - Malbrán and Oswaldo Cruz Foundation (Brazil) (91). Dorta approves his doctoral thesis. An agreement of CABBIO project on entomopathogenic fungi is signed between CINDEFI (Arcas), IMYZA, CENARGEN/EMBRAPA (Brasil) (92). Yantorno renounces the Direction (93), Ertola assumes it. Brelles Mariño approves his doctoral thesis (93). Participation in the Latin American Congress of biotechnology, Chile (Mignone, Voget) (93).
Participation in the VII International Congress of Bacteriology and Applied Microbiology, Prague, Boiardi (94). Hozbor is research grantee of the EEC at the Pasteur Institute in Paris (94). A. Rossa and y Flores approve their doctoral thesis (94). Participation in the VII Biotechnology European Congress, Niza, (Ertola,95). Rodriguez approves his doctoral thesis and obtained an external scholarship (95). Yantorno participates at biotechnology  congress in Havana (95). A.Rossa is external grantee from CONICET at the University of Amsterdam. There are visits of Sakai and Neijssel (94-96). Hours makes a stay in Osaka, Japan, and Rodriguez in Alcalá de Henares, for one month (95). Participation in the 13th Congress Enzyme Engineering, San Diego, (USA) (Voget, 95). Cavalitto does a course in Osaka (95) and is admitted as grantee of initiation CONICET. Prieto, Luna and Vallejo are research grantees of the CIC, the FOMEC and Universidad de San Juan respectively (96). Prize of the Presidency of the Republic, Ertola (96). Flores does a stay at the universities of Oporto and Lisboa, Portugal (96). In the last 5 years, 36 research papers are published in international journals and several post-graduate courses are taught in the country and Latin America (Voget, Mignone, Yantorno, Arcas, Boiardi). In September 96, Neijssel presents to the Direction, but unfortunately a painful illness prevents him from assuming the position, dying the following year.
Mignone assumes the Direction in interim form. The Institute successfully passed an institutional academic and administrative evaluation. The assignment of new spaces at the CINDEFI is achieved in 2002. Donati moved with his group to the Center. More than 50 works are published in international journals. Mignone renounces his position in December 2002, assuming Yantorno in interim form. The regular contest is done and Donati assumes .